• Four polymorphic variants of Neil

  2021-12-16

  

  Four polymorphic variants of Neil1, namely, S82C (rs5745905), G83D (rs5745906), C136R (rs5745907) and D252N (rs5745926) were characterized by Roy et al. in 2007 (Table 1). Analyses of AP site incision on Tg containing oligonucleotide showed that S82C and D252N variants had wild type activity and car

• A further generally applicable approach

  2021-12-16

  

  A further generally applicable approach for the synthesis of N-linked glycopeptides involves the convergent Lansbury aspartylation of glycosylamines. Here, the detrimental formation of aspartimides during the activation of the side chain aspartate can be prevented through the use of Ser/Thr pseudopr

• br Materials and methods br Results br Discussion

  2021-12-16

  

  Materials and methods Results Discussion Our study demonstrates that human GIP(3-30)NH2 is a selective GIPR antagonist that inhibits both GIP-mediated cAMP signaling, β-arrestin recruitment, and GIPR internalization. Furthermore, we demonstrate that human GIP(3-30)NH2 binds with high affini

• Cx mimetic peptides short synthetic peptides corresponding t

  2021-12-16

  

  Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino (-)-JQ1 sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel function in a concentrat

• At the end of experiments rats were injected high dose

  2021-12-16

  

  At the end of experiments rats were injected high dose of sodium pentobarbital (90mg/kg) and the rat’s head was cut and frozen in −20°C for 20min with the injecting tube in situ before section. The location of the tip of the injecting tube was verified and all the tips of the injecting tube were in

• We reviewed the results of

  2021-12-15

  

  We reviewed the results of comprehensive genomic profiling (CGP) in 26,054 cases of NSCLC and examined the frequency and clinical characteristics of patients whose tumors harbor FGFR fusions. To our knowledge, this is the most in-depth evaluation of FGFR fusions exclusively in NSCLC. Here we will de

• In addition to the regulation afforded by calcineurin

  2021-12-15

  

  In addition to the regulation afforded by calcineurin/NFAT axis, it has been shown that deregulation of some microRNAs (e.g. miR-155) can induce activation of Fas/FasL-in various cell types [72]. Furthermore, Fas–FasL interactions appear to be an important mechanism for the maintenance of immune pri

• The mechanism study demonstrated that BDNF

  2021-12-15

  

  The mechanism study demonstrated that BDNF is one of the fundamental mechanisms underlying JMJD2A effects during neuropathic pain. BDNF is a neurotrophin with essential functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels un

• While considering the molecular pathogenesis of an MPNST the

  2021-12-15

  

  While considering the molecular pathogenesis of an MPNST, the Ras/Raf/MEK/ERK, mTOR/AKT, p53, and PTEN pathways associated with tumor growth have been described (McCubrey et al., 2012). The involvement of receptor tyrosine kinases such as EGFR and TAM receptor families, and its associated molecular

• Multi targeting agents are of

  2021-12-15

  

  Multi-targeting agents are of major interest in modern drug design and discovery. Design of such compounds can be applied to H3R antagonists for the purpose of achieving optimum efficiency as performed for some preclinical candidates such as recently for contilisant (Bautista-Aguilera et al., 2017;

• Finally we find that in the absence

  2021-12-15

  

  Finally, we find that in the absence of Aurora B, Sgo1 is delocalized from centromeres and found along chromosome arms, as reported after depletion of Bub1 (Kitajima et al., 2005, Riedel et al., 2006). The increased arm cohesion observed in the absence of Aurora B activity is dependent on the presen

• br Materials and methods br Results br Discussion ENU mutage

  2021-12-15

  

  Materials and methods Results Discussion ENU mutagenesis is a powerful approach to identify novel genes or matrix metalloproteinase to dissect the molecular basis of mammalian immune system (Siggs, 2014). T cells are critical components in the host defense against pathogens, and their activ

• Due to the high structural similarity between

  2021-12-15

  

  Due to the high structural similarity between GlxI and FosA, it is possible that GlxI directed evolution experiments could produce FosA enzymatic activity in a GlxI enzyme. Although the current investigation was unable to detect FosA activity by mutation of a key metal liganding residue in the activ

• br Experimental br Acknowledgment This work was supported in

  2021-12-15

  

  Experimental Acknowledgment This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. Glyoxalase I (GLO1) is a zinc enzyme that catalyzes the isomerization of a hemithioacetal, formed from glut

• br Introduction The generic antifibrinolytic drug tranexamic

  2021-12-15

  

  Introduction The generic antifibrinolytic drug tranexamic neuroscience peptides (TXA) inhibits the protein-protein interaction between plasminogen and fibrin [9]. TXA is frequently used to reduce bleeding in various hemorrhagic conditions, such as during surgical procedures in the heart [19]. Ho

13934 records 488/929 page Previous Next First page 上5页 486487488489490 下5页 Last page